DIAGNOSTIC CRITERIA OF MULTIPLE MYELOMA :
Major:
1.PLasmacytoma
2.Bone marrow plasmacytosis >30% of plasma cells
3.Monoclonal globin spike IgG > 35/L, or IgA >20g/L
4. Light chain excretion on urine electrophoresis > 1g/24hours
Minor:
1.Bone marrow plasmacytosis, 10-30% plasma cells
2.Monoclonal globulin spike, IgG < 35 g/l or IgA <20g/L
3. Lytic bine leaions
4. NOrmal IgM < 500mg/L, IgA < 1g/L or IgG < 6g/l
Criteria
1. 1 major and 1 minor
or
2. 3 minor that should include 1 and 2 of minor criteria.
Reference: Harrison's Principles of Internal Medicine 18th Edition
Major:
1.PLasmacytoma
2.Bone marrow plasmacytosis >30% of plasma cells
3.Monoclonal globin spike IgG > 35/L, or IgA >20g/L
4. Light chain excretion on urine electrophoresis > 1g/24hours
Minor:
1.Bone marrow plasmacytosis, 10-30% plasma cells
2.Monoclonal globulin spike, IgG < 35 g/l or IgA <20g/L
3. Lytic bine leaions
4. NOrmal IgM < 500mg/L, IgA < 1g/L or IgG < 6g/l
Criteria
1. 1 major and 1 minor
or
2. 3 minor that should include 1 and 2 of minor criteria.
Reference: Harrison's Principles of Internal Medicine 18th Edition
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